滥用酒精的多基因风险对年轻成年狂饮者的负面情绪处理的影响
Yu Chen1, Xingguang Luo2, Huey-Ting Li3
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT, 06520, USA. yu.chen.yc838@yale.edu.
Translational psychiatry
|November 21, 2025
概括
滥用酒精的遗传风险与酒者对负面情绪的改变大脑反应有关,特别是在男性中. 这些发现突出了神经生物学途径,将遗传倾向和饮酒问题联系起来.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学是一种遗传学.
- 精神病学是一个精神病学.
背景情况:
- 改变情绪处理在狂饮者中很常见.
- 遗传因素有助于滥用酒精,但它们对情绪反应的影响尚不清楚.
研究的目的:
- 为了调查滥用酒精的遗传风险如何影响大脑和行为反应对负面情绪在狂饮者.
- 探索这些神经生物学反应中的性别差异.
主要方法:
- 利用了人类结合体项目的数据,这些数据来自在情绪任务期间接受fMRI的狂饮和非狂饮饮者.
- 对酒精依赖的量化酒精使用严重程度 (PC1) 和计算的多基因风险得分 (PRS).
- 使用线性回归来评估PC1,PRS和大脑激活之间的关联,控制共变量.
主要成果:
- 较高的酒精使用严重程度 (PC1) 和PRS与过度饮酒者体质投诉的增加相关.
- 过度饮酒者表现出更大的额头,额头,部区域和胰岛的激活,与PRS正相关,特别是在男性中.
- 默认模式网络响应显示性别共享的遗传风险标志物.
结论:
- 滥用酒精的遗传风险与过度饮酒者对负面情绪的神经生物学处理变化有关.
- 研究结果表明,遗传因素影响了涉及问题饮酒的情绪调节途径.
- 需要进行长度研究,以阐明遗传风险,情绪处理和滥用酒精之间的相互作用.
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