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用于抗微生物应用的多生物活性化合物装载纳米载体的合成和性能优化

Zhihai Zhang^1,2, Mengxiao Tantai^1,2, Hui Ma^1,2

¹Orthopaedic Department, Ningxia Medical University General Hospital, Yinchuan, China.

Scientific reports

|November 21, 2025

概括

聚乳-同-甘氨酸纳米颗粒 (PLGA NPs) 成功共载黄素,奎尔塞丁和皮佩林,提高了它们的生物利用性并显示出显著的抗菌活性. 这些生物相容的PLGANP提供了受控释放,改善了疏水化合物的治疗潜力.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

黄素 (Cur),青素 (Que) 和皮佩林 (Pip) 是植物衍生化合物,具有治疗效益,但由于生物利用性差,临床使用有限.
聚乳糖合糖酸纳米颗粒 (PLGA NPs) 为控制药物输送提供了一个有前途的平台,增强了疏水化合物的疗效.

研究的目的:

开发和描述黄素,奎尔素和皮佩林共同装载的PLGA纳米粒子 (Cur-Que-Pip-PLGANP).
评估开发的纳米粒子的物理化学性质,体外药物释放,生物相容性和抗菌活性.

主要方法:

使用乳化溶剂蒸发方法合成了Cur-Que-Pip-PLGANP.
物理化学表征包括TEM,SEM,DLS和HPLC.
使用CCK-8和Calcein AM/PI测定来评估生物相容性,而抗菌活性则通过阿加扩散方法来确定.

主要成果:

在Cur-Que-Pip-PLGA NP中,平均粒子大小为210.6nm,封装效率高 (Cur: 97.1%,Que: 95.5%,Pip: 45.5%).
实验室研究表明,持续释放时间超过96小时,比8小时内释放的自由化合物要慢得多.
这些纳米颗粒显示出出色的稳定性,与各种细胞系具有良好的生物相容性,以及对黄金菌 Staphylococcus aureus 和 Pseudomonas aeruginosa 的显著抗菌活性.

结论:

库尔-奎-皮普-PLGANP具有出色的生物相容性,可控释放能力和强大的抗菌特性.
这些发现表明,Cur-Que-Pip-PLGANP具有显著的潜力,可以提高疏水生物活性化合物的治疗性能.

关键词:

抗微生物药物抗微生物药物描述一个人物的性格.药物输送系统是药物输送系统.纳米颗粒纳米颗粒天然化合物是一种自然化合物.

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