在帕金森病中,与疼痛相关的结构性和功能性大脑变化与疼痛有关
Erlei Wang1, Yujing Jia1, Pubing Yuan2
1Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
NPJ Parkinson's disease
|November 21, 2025
概括
帕金森病的疼痛涉及到大脑结构和连接性的变化,特别是在insula和temporoparietal结. 这些神经变化与疼痛强度相关,为疼痛管理提供了目标.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 神经学 神经学
背景情况:
- 疼痛是帕金森病 (PD) 的一个常见的非运动症状.
- 与PD相关的疼痛背后的精确神经机制尚未完全理解.
- 了解这些机制对于开发有效的疼痛管理策略至关重要.
研究的目的:
- 用先进的神经成像技术研究帕金森病中疼痛的神经基础.
- 为了比较帕金森病患者的脑结构和功能,有和没有疼痛,以及健康的对照.
- 为了确定与PD疼痛相关的潜在成像生物标志物.
主要方法:
- 从65名患有疼痛的PD患者 (PDP),55名没有疼痛的PD患者 (nPDP) 和35名健康的对照人群 (HC) 获得结构性,功能性和扩散性MRI扫描.
- 分析包括局部化指数 (LGI),中心度 (DC),分数异构 (FA) 和功能连接.
- 进行了统计分析,以比较不同组的成像指标,并将它们与疼痛强度相关联.
主要成果:
- 与对照组相比,这两组PD在左前胰岛 (aINS) 的LGI降低,在左上状/状结 (STG/TPJ) 的DC降低,PDP降低更大.
- 在两个PD组中,在腹膜区域/黑色体和双边尾状体中观察到减少的FA.
- 在PD患者中,aINS和STG/TPJ之间的功能连接性下降,特别是那些疼痛患者. 在PDP患者中,LGI和FA与疼痛强度相关.
结论:
- 与PD相关的疼痛与特定大脑区域的结构和功能变化有关,包括aINS和STG/TPJ.
- 降低多巴胺基通路 (VTA/SN) 和条纹体的完整性,以及受损的岛膜-膜-膜连接,可能会导致疼痛.
- 这些神经成像发现为PD疼痛的病理生理学提供了洞察力,并建议潜在的治疗点.
相关概念视频
Parkinson's Disease: Overview
1.7K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.7K
Neural Regulation
43.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.0K
Parkinson's Disease: Treatment
953
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
953
Brainstem
5.6K
The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
5.6K


![Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F53947.jpg&w=3840&q=50)