肺组织T细胞在慢性阻塞性肺病中被激活,而非小细胞肺癌患者则被激活
Mari Tone1,2,3, Tomomi Isono4, Yoko Yamamoto4
1Department of Cancer Immunotherapy, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Scientific reports
|November 21, 2025
概括
患有慢性阻塞性肺病 (COPD) 和非小细胞肺癌 (NSCLC) 的患者在肺组织中显示T细胞增加. 这些发现支持对患有COPD的NSCLC患者的免疫治疗.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
背景情况:
- 慢性阻塞性肺病 (COPD) 与增加肺癌风险有关.
- 患有COPD的非小细胞肺癌 (NSCLC) 患者可能受益于抗PD-1/PD-L1免疫疗法.
- 患有COPD的NSCLC患者的T细胞概况需要进一步调查免疫治疗的合理性.
研究的目的:
- 研究患有或没有COPD的NSCLC患者肺组织中的T细胞概况和功能.
- 为患有COPD的NSCLC患者提供免疫治疗的理由.
主要方法:
- 在肺瘤和非瘤组织中分析T细胞群 (PD-1+,Tim-3+,CD103+T细胞).
- 与IFN-γ生产和COPD临床参数 (吸烟史,FEV1/FVC比率) 的T细胞丰度的相关性.
主要成果:
- 患有COPD的NSCLC患者在瘤组织中含有大量PD-1+和Tim-3+T细胞.
- CD103+组织内存T (T_RM) 细胞在患有COPD的NSCLC患者的非瘤组织中更为丰富.
- CD103+ T_RM细胞丰度与IFN-γ和COPD临床参数相关.
结论:
- T细胞在患有COPD的NSCLC患者的瘤和非瘤肺组织中都很活跃.
- 这些发现表明,在患有COPD的NSCLC患者中,免疫疗法可能会产生反应.
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