脊髓神经调节用于控制血压,使用低强度聚焦超声波
Angelica F Lopez1,2, Denis Routkevitch1,2,3, Patrick J Kramer2,3
1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Scientific reports
|November 21, 2025
概括
低强度聚焦超声波 (LIFU) 可以通过刺激大鼠脊髓来非侵入性调节血压. 这项技术对治疗血压障碍而没有药物的治疗有前途.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 心血管生理学心血管生理学
背景情况:
- 聚焦超声波 (FUS) 是一种新兴的技术,用于有针对性的能量传递.
- 以前的FUS应用包括瘤切除和药物输送到大脑.
- 在脊髓神经调节方面,FUS的潜力在很大程度上仍未被探索.
研究的目的:
- 为了研究低强度FUS (LIFU) 对脊髓的影响.
- 确定 LIFU 调节大鼠平均动脉压 (MAP) 的能力.
- 探索刺激位置和持续时间对MAP调制的影响.
主要方法:
- 在不同的水平 (胸部和腰部神经) 上,LIFU 应用于大鼠暴露的脊髓.
- 在LIFU刺激期间和之后,对MAP进行了持续监测.
- 测试了30秒和90秒的刺激时间.
主要成果:
- LIFU刺激调节了MAP,降低了它在下胸部水平,增加了它在 lumbosacral水平.
- 较短的刺激时间 (30秒) 比较长的时间 (90秒) 更有效地降低了MAP.
- 重复LIFU刺激导致MAP恢复时间增加,使其恢复到基线.
结论:
- LIFU可以在非药理和空间上准脊髓通路,以控制MAP.
- 这种方法有可能用于管理像自主反射障碍和高血压等血压障碍.
- 对FUS神经调节的进一步研究可能会导致针对心血管疾病的新型临床干预.
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