通过炎症和饮食模式调解和适度重金属暴露对功能的影响
Zhaoyang Zhong1,2,3,4,5,6,7, Zhengqi Wei8, Jincheng Liu9,10,11,12,13,14,15
1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China.
Scientific reports
|November 21, 2025
概括
暴露于重金属会通过增加炎症来损害功能,但饮食可以影响这一点. 促进炎症的饮食会使重金属对脏的损伤恶化,而健康的饮食则会提供保护.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 毒理学 毒理学 毒理学
背景情况:
- 重金属是公认的毒素,可能会增加慢性病风险.
- 炎症反应,饮食模式和重金属毒性之间的相互作用尚未得到充分理解.
研究的目的:
- 为了研究连接重金属暴露,炎症和功能下降的途径.
- 探索饮食模式如何调节重金属诱导的损伤.
主要方法:
- 利用了通用线性模型,受限制的立方支线模型和加权定量回归.
- 评估血液和尿液中的重金属含量,功能标志物 (eGFR,UACR) 和全身炎症 (SIRI).
- 采用调解和适度分析来检查炎症途径和饮食影响.
主要成果:
- 暴露于大多数血液和尿路重金属与降低EGFR,增加UACR和升高SIRI相关.
- 血液中的和以及尿中的和对功能标志物产生显著影响.
- 炎症 (SIRI) 调解了重金属和功能之间的关系,饮食模式 (DII,HEI2020) 缓解了这些影响.
结论:
- 接触重金属会对功能产生负面影响,部分是通过炎症途径.
- 饮食炎症指数和健康饮食指数2020显著影响重金属毒性,强调饮食是减轻损伤的关键因素.
相关概念视频
Chronic Kidney Disease III: Interprofessional Care
326
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
326
Acute Kidney Injury IV: Diagnostic Studies and Prevention
249
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
249
Acute Kidney Injury V: Interprofessional Care
284
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
284
Inflammatory Response
15.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.9K
Acute Kidney Injury VI: Nursing Management
371
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
371
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
343
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
343


