基质利用和交叉养协同决定了微生物群对病原体入侵的抵抗力
Xinrun Yang1, Tianjie Yang2, Ziru Zhang1
1Jiangsu Provincial Key Lab for Solid Organic Waste Utilization, Key Lab of Organic-based Fertilizers of China, Jiangsu Collaborative Innovation Center for Solid Organic Wastes, Educational Ministry Engineering Center of Resource-saving fertilizers, Nanjing Agricultural University, Nanjing, China.
Nature ecology & evolution
|November 22, 2025
概括
植物微生物组通过交叉养相互作用抵抗病原体. 了解这些微生物网络有助于设计抗病植物和生态系统.
科学领域:
- 微生物学 微生物学
- 植物病理学 植物病理学
- 系统生物学 系统生物学
背景情况:
- 与植物相关的微生物组对生态系统健康至关重要.
- 植物病原体的入侵对自然和农业系统构成重大威胁.
- 微生物组介导的病原体抑制机制尚未完全理解.
研究的目的:
- 研究植物相关微生物群落抑制植物病原体入侵的机制.
- 用基因组规模的代谢模型和合成社区实验来预测病原体入侵结果.
- 为了确定关键的微生物相互作用和代谢特征驱动社区耐药性.
主要方法:
- 为个别微生物菌株开发精选的基因组规模代谢模型.
- 纳入48个共同的资源利用概况来评估代谢能力.
- 在体外和植物内合成社区实验以测试模型预测.
- 热带相互作用和交叉食代谢物动态的分析.
主要成果:
- 从代谢模型推断出的热量相互作用准确地预测了病原体入侵结果.
- 在本土社区内交叉养的代谢物被确定为对抗性的关键.
- 代谢物交叉养不成比例地有利于本地物种而不是入侵的病原体.
- 对病原体抑制的整体理解需要考虑基质和代谢物利用.
结论:
- 基因组规模的代谢模型与合成社区相结合,可以阐明微生物组的功能.
- 交叉养相互作用是植物微生物组对病原体耐药性的关键驱动因素.
- 这项研究为设计抗病微生物组提供了一个框架.
- 这些发现对减轻各种环境中的病原体影响具有广泛的意义.
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