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Updated: Jan 10, 2026

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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Published on: September 8, 2012

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在III-B型CRISPR-Cas系统中SAM-AMP合成和降解的分子基础

Benzhen Duan1, Xiaohui Jin1, Xiaoman An1

  • 1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Fifth People's Hospital, Shanghai Institute of Infectious Disease and Biosecurity, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.

Nature chemical biology
|November 22, 2025
PubMed
概括

在 Bacteroides fragilis 中的III-B型CRISPR-Cas系统使用一种新的RNA识别机制来合成SAM-AMP,激活免疫反应. 这一过程涉及SAM-AMP的特定构造变化和独特的降解途径.

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