除了胰腺炎之外的胰腺外分泌功能不全
1Institute of Digestive and Liver Diseases, BLK-Max Super Speciality Hospital, New Delhi, 110 005, India. nehaberry86@hotmail.com.
概括
胰腺外分缺陷 (PEI) 导致由于消化酶不足而导致消化不良. 本综述探讨了PEI的非胰腺炎原因以及胰腺酶替代疗法 (PERT) 的作用.
科学领域:
- 胃肠病学 胃肠病学
- 消化系统生理学 消化系统生理学
背景情况:
- 胰腺外分泌功能缺陷 (PEI) 是由于消化酶的释放不足或过早失活,导致消化不良.
- 虽然慢性胰腺炎是常见的原因,PEI可能源于各种疾病,包括胰腺瘤,囊性纤维化和炎症性肠道疾病.
- 临床上显著的PEI主要与脂酶不足有关,其中分泌量下降到正常水平的10%以下,表明PEI严重.
研究的目的:
- 审查导致PEI的胰腺炎以外的疾病.
- 阐明这些条件导致PEI的机制.
- 评估胰腺酶替代疗法 (PERT) 在治疗由这些多种疾病引起的PEI方面所带来的潜在益处.
主要方法:
- 关于PEI和吸收不良的研究的文献综述.
- 在非胰腺炎疾病中分析PEI的病因因素.
- 评估PERT在各种PEI环境中的作用和有效性.
主要成果:
- 在胰腺癌,囊性纤维化,糖尿病和IBD等疾病中,PEI是吸收不良的重要原因.
- 脂酶缺乏率低于正常水平的10%是严重PEI的关键值,也是PERT的明确迹象.
- PEI的机制因病情而异,涉及对酶损失,管道阻塞,刺激减少或酶失活.
结论:
- 除胰腺炎外,PEI还发生在许多疾病中,影响营养吸收.
- PERT适用于严重的PEI,主要是由脂酶不足引起的.
- 需要进一步调查以确定PEI在各种非胰腺炎相关疾病的最佳管理策略,包括PERT.
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