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长期COVID-19患者的持续炎症性细胞因子签名:一个元分析

Waleska Dornas¹, João Pedro Reis², Tales Eduardo Belilo²

¹Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, 30270-901, Brazil. dornasw@gmail.com.

Inflammopharmacology

|November 22, 2025

概括

COVID-19 (PASC) 后急性后果包括持续的症状. 像IL-6和TNF-α这样的高细胞因子水平表明持续的炎症有助于长期的Covid,为免疫病理提供了洞察力.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
病理学病理学病理学

背景情况:

COVID-19 (PASC) 后急性后果是一个重大挑战,其生物机制和治疗目标不明确.
了解SARS-CoV-2感染后的免疫反应对于解决慢性症状至关重要.

研究的目的:

系统地分析PASC患者的细胞因子水平.
为了确定与持续的Covid-19症状相关的潜在炎症生物标志物.

主要方法:

在PubMed/MEDLINE,Web of Science和Scopus数据库中进行系统的文献搜索,截至2024年12月.
从33项涉及3294名患有或没有PASC的患者的研究中对细胞因子水平的元分析.
根据感染后的持续时间 (<6个月和≥6个月) 分类细胞因子测量.

主要成果:

在PASC患者中观察到IL-6,IL-2,MCP-1/CCL2,TNF-α,IFN-γ和IP-10/CXCL10的升高水平.
在感染后6个月内,IL-6,MCP-1/CCL2,TNF-α和IFN-γ的水平仍然升高.
包括IL-1β,IL-8,IP-10/CXCL10,IL-2和IL-10在内的特定细胞因子在6个月后显示水平增加.

结论:

特定炎症性细胞因子持续升高与PASC有关.
这些发现表明,Covid-19的长期后果的炎症基础是COVID-19.
这项研究有助于了解慢性Covid-19功能障碍背后的免疫病理.

关键词:

细胞因子 (cytokines) 是一种细胞因子.免疫反应的免疫反应.炎症炎症是一种炎症.长时间的Covid.帕斯克 (PASC) 是一个过去.这就是SARS-CoV-2病毒.症状症状症状

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