在不同抗瘤治疗方式中对患有非小细胞肺癌的男性和女性的预后差异进行了比较研究
Feiyang Li1, Fang Li2, Haowei Lu1
1Department of Medical Oncology, Lixin People's Hospital of Bozhou City, Bozhou, Anhui, Lixin 236700, China.
BMC cancer
|November 22, 2025
概括
男性非小细胞肺癌 (NSCLC) 患者的预后比女性更差,死亡风险更高,特别是当他们接受EGFR-TKI治疗时. 性别是NSCLC的独立预后因素,影响生存结果.
科学领域:
- 在瘤学瘤学.
- 医学研究 医学研究
- 临床试验 临床试验
背景情况:
- 非小细胞肺癌 (NSCLC) 是全球癌症相关死亡的主要原因.
- 了解包括性别在内的预后因素对于优化治疗策略至关重要.
- 以前的研究表明NSCLC结果可能存在基于性别的差异,但需要进一步调查.
研究的目的:
- 为了调查男性和女性患有NSCLC的患者之间的预后差异.
- 分析各种抗瘤治疗方式对性别特异性结果的影响.
- 确定影响NSCLC预后差异的潜在因素.
主要方法:
- 在2018年至2024年期间诊断出715名NSCLC患者的回顾性分析.
- 倾向性得分与基线人口和临床性别不平衡的对照匹配.
- 卡普兰-梅尔生存分析,日志等级测试和多变量考克斯回归来评估预后差异.
主要成果:
- 男性NSCLC患者的死亡风险明显高 (29.2%),与女性的死亡风险相比.
- 在EGFR-TKI亚组中,男性的死亡风险比女性高49%;在免疫检查点抑制剂中没有发现显著差异.
- 多变量分析证实男性性别是增加死亡风险的独立预测因素 (HR=1.31).
结论:
- 性别是NSCLC的独立预后因素,男性通常经历较短的整体存活期.
- 预后差异在接受EGFR-TKI治疗和特定临床阶段的患者中尤其明显.
- 临床决策应考虑性别作为预后因素,需要进一步研究以阐明潜在的生物机制.
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