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与成人体重变化和早期成人BMI相关的COPD风险:一项前性队列研究
Lu Chen1, Wei Yu1, Dianjianyi Sun1,2,3
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Beijing, 100191, China.
在成年期保持健康的体重与男性慢性阻塞性肺病 (COPD) 风险降低有关. 极端的体重波动会增加女性的COPD风险.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 肺部病理学 肺部病理学
背景情况:
- 肥胖和慢性阻塞性肺病 (COPD) 的联系尚不清楚,阻碍了体重干预政策.
- 成年早期的脂肪和成人体重变化是预防COPD的关键因素.
研究的目的:
- 研究成年期体重变化,早期成年期体重指数 (BMI) 和COPD风险之间的关联.
- 分析这些关联中的性别特异性差异.
主要方法:
- 利用了中国Kadoorie生物库的前景队列 (2004-2008) 共有332,943名参与者 (35-70岁).
- 定义的体重变化是基线和25岁体重之间的差异.
- 采用Cox比例危险模型来评估与体重参数相关的COPD风险.
主要成果:
- 在11.9年的时间里,记录了3732例男性和3154例女性COPD病例.
- 在男性中,在成年早期更健康的体重变化和BMI与较低的COPD风险相关.
- 早期成年期肥胖 (BMI ≥28.0) 在非吸烟男性中增加了慢性肺炎风险 (HR=1.76).
- 在女性中,极度减肥或体重增加显著增加了COPD风险.
- 体重变化对低体重和肥胖的早期成年人群中COPD风险的影响更为明显.
结论:
- 成年体重动态和早期的BMI与男性的COPD风险相反相关.
- 显著的体重波动 (损失或增加) 会增加女性的COPD风险.
- 调查结果强调了体重管理对预防COPD的重要性,并考虑了性别特异性因素.
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