认知功能的调解作用在牙脱落和抑郁症状之间的关联:一个横截面研究
Huang Shi-Jia1, Hu Ze-Long2, Qian Yu-Xin3
1Department of Orthodontics & Prosthodontics, the Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, 310000, China.
BMC oral health
|November 22, 2025
概括
完全失去牙与老年人更高的抑郁率有关. 认知功能显著调解了这种关系,解释了超过60%的总影响. 这凸显了口腔健康对心理健康的重要性.
科学领域:
- 老年学与公共卫生
- 神经科学和心理健康
- 牙和口腔健康科学 牙和口腔健康科学
背景情况:
- 抑郁症是老年人群的主要健康问题.
- 牙病 (牙损失) 是抑郁症的一个疑似危险因素,但机制尚不清楚.
研究的目的:
- 研究中老年人和老年人的牙脱落,认知功能和抑郁症状之间的联系.
- 确定认知功能是否调解了牙脱落和抑郁症之间的关联.
主要方法:
- 来自2018年中国健康与退休长度研究 (CHARLS) 的横截面数据的二次分析.
- 11,000名参与者 (平均年龄为60.8岁) 评估了抑郁症状 (CES-D-10) 和牙损失 (自我报告).
- 用于评估认知功能 (定向,记忆,计算,视觉空间技能) 的调解作用的因果调解分析.
主要成果:
- 在多变量逻辑回归模型中发现了牙损失和抑郁症之间的显著关联.
- 认知功能占牙脱落对抑郁症总影响的61.6% (ACME:0.043).
- 牙脱落对抑郁的平均直接影响为0.024.
结论:
- 完全失去牙与全国代表性队列中抑郁症患病率增加有关.
- 认知障碍在牙损失-抑郁路径中起着重要的调解作用.
- 这项研究首次量化了认知在这种关系中的调解效应.
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