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系统性免疫炎症指数与心肌梗塞患者的死亡风险之间的关联:一个回顾性队列研究

Baobin Cui¹, Yufei Sun¹, Di Cao²

¹Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.

European journal of medical research

|November 22, 2025

概括

系统性免疫炎症指数 (SII) 显示了J形与心肌梗塞 (MI) 后死亡率的联系. 770 × 109/L以上的高SII水平独立预测不良结果,有助于早期风险分层.

科学领域:

心脏病学心脏病学
免疫学免疫学免疫学
生物标志物研究生物标志物研究

背景情况:

系统性免疫炎症指数 (SII) 是各种疾病的潜在预后生物标志物.
它在预测心肌梗塞 (MI) 后死亡率方面的作用需要进一步研究.

研究的目的:

检查系统性免疫炎症指数 (SII) 与被诊断为心肌梗塞 (MI) 的患者的死亡率之间的关联.

主要方法:

以MIMIC-IV和哈尔医科大学癌症医院的数据为依据的回顾性队列研究.
分析四个SII季度的28,90和180天死亡率.
卡普兰-梅尔曲线,考克斯回归和限制立方线 (RCS) 用于评估死亡风险和非线性关系.

主要成果:

在SII和死亡风险之间观察到一个显著的J形非线性关联,最低风险约为770 × 109/L.
与最低四分位数 (Q1) 相比,最高SII四分位数 (Q4) 在28,90和180天的死亡率显著增加.
多变量分析确定SII是28天死亡率的独立预测因素,特别是在患有充血性心力衰竭的患者中.

结论:

系统性免疫炎症指数 (SII) 显示出对心脏病后死亡率的值效应.
超过770 × 109/L的SII值是不利结果的独立预测指标.
SII具有作为预后工具的潜力,用于早期心脏病发作患者的风险分层.

关键词:

死亡率; 密集护理-IV的医疗信息中心.心肌梗塞的心脏病发作有限制的立方线.系统性免疫炎症指数

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