在孕期暴露于PM2.5的母婴双中明显的DNA甲基化
Eleanor Klibaner-Schiff1, Elisabeth M Simonin1, Abhinav Kaushik1
1Department of Environmental Health, T.H. Chan School of Public Health, Harvard University, 677 Huntington Ave, Boston, MA, 02115, USA.
Clinical epigenetics
|November 22, 2025
概括
产前暴露于空气污染可能会改变母亲和婴儿的DNA甲基化. 这项试点研究发现,与PM2.5暴露相关的母体血细胞和婴儿带血细胞的明显表观遗传变化.
科学领域:
- 环境表观遗传学环境表观遗传学
- 围产期健康 围产期健康
- 免疫发展 免疫发展
背景情况:
- 怀孕期间的空气污染与儿童过敏和呼吸道疾病风险增加有关.
- 人们怀疑表观遗传机制,如DNA甲基化,可以调解这些效应.
- 了解母胎界面上的这些变化对于评估健康风险至关重要.
研究的目的:
- 调查产前空气污染暴露与DNA甲基化模式之间的关联.
- 为了比较母体外围血液单核细胞 (PBMC) 和婴儿带血单核细胞 (CBMC) 的DNA甲基化差异.
- 为了确定受颗粒物 (PM2.5) 暴露影响的特定表观遗传位置.
主要方法:
- 在加利福尼亚州弗雷斯诺附近对10个母婴双进行试点研究.
- 使用定制阵列针对过敏和喘相关基因的DNA甲基化分析.
- DNA甲基化数据与PM2.5暴露水平的相关性.
主要成果:
- 在与PM2.5暴露相关的母体PBMC中确定了24个CpG位点.
- 在婴儿CBMC中确定了18个CpG位点,与PM2.5暴露有关.
- 在母婴样本中只发现了一个共享的CpG位点,表明不同的反应.
结论:
- 产前的PM2.5暴露与母亲和婴儿的差异性DNA甲基化有关.
- 母亲和胎儿对空气污染的表观遗传反应似乎在很大程度上是不同的.
- 需要进一步的研究来验证这些发现,并探索对免疫发育和疾病风险的功能影响.
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