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血管内皮生长因子:尤文肉瘤的潜在预后因子
Goutam Santosh Panda1, Arun Chandrasekharan, Bharat Rekhi
1Department of Medical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Dr. E Borges Road, Parel, Mumbai, Maharashtra, India.
Indian journal of cancer
|November 22, 2025
概括
血管内皮生长因子 (VEGF) 是转移性尤宁肉瘤 (ES) 的显著预后标志物. 较高的VEGF表达表明较差的结果,这表明高级ES的潜在治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 血管内皮生长因子 (VEGF) 是一个关键的血管生成因子,参与癌症的发展和预后.
- 在尤文肉瘤 (ES),一种罕见的骨癌中,VEGF的预后价值需要进一步调查.
研究的目的:
- 为了评估Ewing肉瘤患者VEGF表达的预后意义.
- 为了确定VEGF免疫表达是否与转移性ES的生存结果相关.
主要方法:
- 分析了105例经组织病理学证实的尤文肉瘤病例 (2014-2018).
- 在瘤组织上进行的VEGF免疫组织化学染色.
- VEGF强度的分类和与临床数据的相关性,包括转移状态和存活率.
主要成果:
- 在非转移性 (n=53) 和转移性 (n=52) ES队列中分析了VEGF免疫染色模式.
- 转移性ES患者>25%的VEGF阳性瘤细胞或中度/强度免疫染表现出明显较低的整体存活率 (OS) (P = 0.008).
- 以前没有接受过治疗的转移性患者的生存状况较差,而接受了最终手术并完成治疗的患者的生存状况更好.
结论:
- VEGF被确定为转移性尤文肉瘤的独立预后标志物.
- 这些发现表明,在高级ES中向VEGF的潜在治疗含义.
- 建议在更大的前性研究中进一步验证.
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