来自CAF的IL-33介导的EMT促进LSCC细胞的转移
Liyun Yang1, Jieyu Zhou2,3,4, Shiyan Chen5
1Department of Otolaryngology, Shanghai Pudong New Area Gongli Hospital, Shanghai, 200135, China. andyyangliyun@163.com.
European journal of medical research
|November 22, 2025
概括
来自癌症关联纤维细胞 (CAFs) 的中介素-33 (IL-33) 通过介导上皮层-介质细胞过渡 (EMT) 来促进喉平细胞癌 (LSCC) 转移. 沉默IL-33抑制LSCC细胞迁移和入侵.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 细胞信号传输 细胞信号传输
背景情况:
- 喉状细胞癌 (LSCC) 的转移是复杂的,涉及瘤细胞和癌症相关纤维细胞 (CAF).
- 表皮-介质细胞过渡 (EMT) 是LSCC转移的一个关键过程.
- 驱动LSCC转移的精确机制需要进一步阐明.
研究的目的:
- 为了研究介质素-33 (IL-33) 在LSCC转移中的作用.
- 探索CAFs和LSCC细胞在促进转移中的相互作用.
- 为了确定LSCC的潜在治疗点.
主要方法:
- 使用伤口愈合试验评估LSCC细胞迁移.
- 通过免疫光和西欧斑点评估蛋白质表达.
- 在体外和体内使用转移模型量化LSCC细胞迁移和入侵.
主要成果:
- 介素-33 (IL-33) 显著增强了LSCC细胞迁移,入侵和EMT.
- 在与CAF共同培养模型中的IL-33沉默减少了LSCC细胞转移在体外和体内.
- 来自CAFs的IL-33在LSCC进展中起着至关重要的作用.
结论:
- 由CAFs衍生的IL-33调解EMT,从而促进LSCC转移.
- 这项研究揭示了CAF激活和LSCC转移的新机制.
- 这些发现为改善LSCC预防和治疗策略提供了潜力.
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