艾滋病毒感染者心血管风险评分的截面比较
Maria Hernandez-Pereira1, Juan Du1,2, Jade Soldado-Folgado2,3
1Medicine and Life Sciences Department (MELIS), Universitat Pompeu Fabra, Barcelona, Spain.
HIV medicine
|November 22, 2025
概括
心血管疾病 (CVD) 风险评分显示,艾滋病毒感染者的一致性较差,可能低估了风险. 这凸显了需要HIV特异性风险预测工具来准确评估心血管疾病的必要性.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 艾滋病毒感染者面临心血管疾病 (CVD) 风险升高.
- 一般人群的心血管疾病风险得分可能低估了这一群体的风险.
- 准确的风险评估对于预防策略至关重要.
研究的目的:
- 评估五种心血管疾病风险预测模型在艾滋病毒感染者中的一致性.
- 在不同的模型中比较风险类别分布.
- 为这一群体确定最适合的风险评估工具.
主要方法:
- 在西班牙巴塞罗那对246名参与者 (18至75岁) 的横截面研究.
- 使用SCORE2,REGICOR,REGICOR 3.0,D:A:D降低和D:A:D完整模型计算10年心血管疾病风险.
- 统计分析包括千二测试,邦费罗尼校正,林的一致性相关系数 (CCC) 和布兰德-阿尔特曼分析.
主要成果:
- 风险类别分布在模型中的显著差异 (p < 0.001).
- 高风险分类差异很大:REGICOR 3.0 (44.4%) 和D:A:D完全 (41.9%) 发现的非常高风险个体比REGICOR (66.2%低风险) 更多.
- 在D:A:D模型 (CCC=0.82) 之间一致性最高,在大多数一般人群和HIV特定模型之间一致性较差 (<0.5),有系统偏差.
结论:
- 现有的心血管风险评分显示,艾滋病毒感染者之间的一致性和可互换性有限.
- 这些差异凸显了一般人口模型对于这一群体的不足.
- 经过验证,适应艾滋病毒的工具对于精确评估艾滋病毒感染者的心血管疾病风险至关重要.
更多相关视频
07:29Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
9.7K
05:53Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
17.0K
相关概念视频
01:12Relative Risk
1.8K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
1.8K
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
522
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
522
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
537
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
537
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
769
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
769
01:23Assessment of the Cardiovascular System I: Subjective Data
740
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
740
01:26Coronary Artery Disease IV: Preventive Measures
577
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
577