相关实验视频

Updated: Jan 10, 2026

Nasal Potential Difference to Quantify Trans-epithelial Ion Transport in Mice

Nasal Potential Difference to Quantify Trans-epithelial Ion Transport in Mice

Published on: July 4, 2018

口服西奥菲林对创伤性解剖症的影响:一个前性的随机临床试验

Yi-Fang Chiang¹, Rong-San Jiang^2,3,4,5

¹School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Ear, nose, & throat journal

|November 22, 2025

概括

口服西奥菲林与嗅觉训练 (OT) 结合,改善了创伤性厌氧症患者的单边嗅觉功能. 这种组合疗法在气味恢复方面显示出比单独的OT更好的结果.

科学领域:

神经学神经学
耳鼻喉科耳鼻喉科耳鼻喉科
药理学药理学是指药理学的学科.

背景情况:

创伤性厌氧症,或因受伤而失去嗅觉,在治疗中提出了重大挑战.
理论在促进神经嗅觉信号传递和感官轴突再生方面显示出潜力.
研究用于嗅觉功能障碍的新型治疗方法至关重要.

研究的目的:

为了评估口服神素与嗅觉训练 (OT) 结合治疗创伤性厌氧症的疗效.
为了比较组合治疗 (神叶素+OT) 与单独OT的结果.

主要方法:

一项随机对照试验,涉及创伤性完全无氧化症患者.
神灵素组接受了口服神灵素 (400毫克每天两次) 加上OT6个月.
对照组仅在6个月内接受了OT.
嗅觉功能使用乙醇 (PEA) 气味检测门测试和宾夕法尼亚大学气味识别测试 (UPSIT-TC) 进行评估.

主要成果:

在神素加OT组中,单边右侧PEA值显著改善 (P=.018).
仅在OT组中没有观察到PEA值的显著改善 (P=.317).
与仅服用OT的组相比,theophylline组表现出明显更好的PEA值改善 (P=.027).
两组都没有显著改善UPSIT-TC分数.

结论:

口服西奥菲林与嗅觉训练的联合疗法为创伤性厌氧症提供了有前途的治疗方法.
素可以增强嗅觉恢复,特别是改善嗅觉检测值.
需要进一步的研究来探索对气味识别的影响.

关键词:

嗅觉训练是通过嗅觉训练进行的.聚乙醇气味检测门测试试验美国的Theophylline公司.宾夕法尼亚大学香味识别测试的传统中文版本.创伤性解热症是什么

更多相关视频

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols

Published on: May 20, 2016

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

相关概念视频

Olfactory Receptors: Location and Structure

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...