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对pH敏感的金属有机框架通过叶酸受体介导向和级联CDT效应改善了HepG2细胞的抑制

Chen Zhang^1,2,3, Xueyu Pu^1,2,3, Guohua Teng^1,2,3

¹National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China.

Advanced healthcare materials

|November 22, 2025

概括

这项研究开发了一种新型的pH响应药物递送系统 (DDS),使用装载着白醇的改性金属有机框架 (MOF). DDS有效地抑制HepG2肝癌细胞,并显示出联合癌症治疗的前景.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

金属有机框架 (MOF) 显示出有针对性的药物输送的潜力.
肝癌HepG2细胞是新的治疗策略的目标.
开发有效的药物输送系统 (DDS) 对癌症治疗至关重要.

研究的目的:

创建一个pH响应的DDS,以增强抑制HepG2细胞.
为了将白醇 (RES) 装入功能化MOF以进行有针对性的输送.
评估DDS的抗癌疗效和瘤透率.

主要方法:

用Fe-Cu纳米粒子合的UiO-66-NH2 MOF的溶热合成.
用聚多巴胺 (PDA) 和叶酸 (FA) 进行修改,以产生Fe-Cu@MOF-PDA-FA.FA.
使用HepG2细胞和3D模型进行的复星 (RES) 载荷和体外/体内评估.

主要成果:

Fe-Cu@MOF-PDA-FA证明了高药物加载效率和pH响应的RES释放.
DDS表现出较低的细胞毒性和对HepG2细胞显著的抑制作用.
通过FR介导的内细胞分裂观察到瘤透的增强,并增加了ROS生成.

结论:

RES@Fe-Cu@MOF-PDA-FA是癌症治疗中的一个有希望的pH响应的DDS.
DDS将药物输送与化学动力学疗法 (CDT) 结合起来,以改善抗癌活性.
这种方法为向治疗肝癌提供了一种新的策略.

关键词:

化学动力学疗法是一种化学动力学疗法.组合疗法治疗组合治疗.金属有机框架响应pH的向药物输送.瘤微环境 (TME) 是指瘤的微环境.

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