Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Protein Organization01:24

Protein Organization

9.0K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
9.0K
Protein Organization01:13

Protein Organization

155.4K
Overview
155.4K
Protein Families02:47

Protein Families

16.6K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
16.6K
Protein Folding01:25

Protein Folding

10.9K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
10.9K
Protein Folding01:22

Protein Folding

125.7K
Overview
125.7K
Protein and Protein Structures02:15

Protein and Protein Structures

18.1K
18.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Structural motif search across the protein universe with Folddisco.

Nature biotechnology·2026
Same author

A novel method to select Reference Proteomes in UniProt.

bioRxiv : the preprint server for biology·2026
Same author

On the state of protein function prediction: a report on the fourth CAFA challenge.

bioRxiv : the preprint server for biology·2026
Same author

PDBe-SIFTS: an open-source tool for Structure Integration with Function, Taxonomy, and Sequences, featuring improved alignment, scoring scheme, and accelerated search.

bioRxiv : the preprint server for biology·2026
Same author

Advances in Protein Function Prediction from the Fifth CAFA Challenge.

bioRxiv : the preprint server for biology·2026
Same author

Simple and Thorough Detection of Related Sequences with Position-Varying Probabilities of Substitutions, Insertions, and Deletions.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026
Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026
Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026
Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026
Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026
Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026
查看所有相关文章

相关实验视频

Updated: Jan 6, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.5K

2025年AlphaFold蛋白结构数据库:重新设计的界面和更新的结构覆盖.

Damian Bertoni1, Maxim Tsenkov1, Paulyna Magana1

  • 1European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, CB10 1SD,United Kingdom.

Nucleic acids research
|November 22, 2025
PubMed
概括
此摘要是机器生成的。

阿尔法蛋白结构数据库 (AFDB) 现在包括更新的蛋白质结构和重新设计的界面,以方便探索. 这种增强的资源支持结构生物学研究,通过提供访问数以百万计的蛋白质预测.

更多相关视频

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.0K
Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

2.5K

相关实验视频

Last Updated: Jan 6, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.5K
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.0K
Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

2.5K

科学领域:

  • 结构生物学是结构生物学.
  • 生物信息学是一种生物信息学.
  • 计算生物学是一种计算生物学.

背景情况:

  • 阿尔法蛋白结构数据库 (AFDB) 是访问蛋白质结构预测的关键资源.
  • 它已在生命科学研究中得到广泛采用,并集成到各种生物信息学工具中.
  • 之前的版本需要更新以纳入新数据并改善用户体验.

研究的目的:

  • 将AlphaFold蛋白质结构数据库 (AFDB) 更新为最新的UniProt发布 (2025_03).
  • 为了改善可用性,可访问性和结构性解释,重新设计AFDB入口页面.
  • 扩大结构覆盖范围,提高数据可访问性.

主要方法:

  • 数据库更新与UniProt 2025_03版本保持一致.
  • 重新设计的入口页面与集成的注释和一个交互式3D浏览器.
  • 在结构覆盖中包含异形和多重序列对齐.

主要成果:

  • AFDB已更新为UniProt 2025_03,提供了数以百万计的高精度蛋白质结构预测.
  • 一个重新设计的入口页面具有集成的注释,一个交互式3D浏览器,以及专用的域名和摘要选项卡.
  • 扩展的结构覆盖范围现在包括异构形和多个序列对齐.

结论:

  • 更新后的AFDB增强了研究人员的可用性和可访问性.
  • 该数据库仍然是探索蛋白质序列结构关系的重要,可持续的资源.
  • 新功能有助于更深入的结构解释和数据集成.