在COVID-19住院患者的康复性血中
Zoe McQuilten1, Matthew V N O'Sullivan2,3,4, Damien Purcell5
1School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Internal medicine journal
|November 22, 2025
概括
康复性血 (CP) 显示出降低死亡率的趋势,并且需要在COVID-19患者中提供密集支持. 然而,澳大利亚COVID-19试验 (ASCOT) 提前停止,限制了关于CP疗效的最终结论.
科学领域:
- 传染性疾病 传染性疾病
- 临床试验 临床试验
- 免疫学 免疫学 免疫学
背景情况:
- 康复性等离子体 (CP) 作为潜在的COVID-19疗法在流行病的早期出现.
- 澳大利亚COVID-19试验 (ASCOT) 是为了调查CP的有效性而启动的.
研究的目的:
- 评估康复性血 (CP) 的疗效和安全性,用于治疗COVID-19的住院成年人.
- 评估CP对死亡率的影响以及需要密集呼吸或血管压缩器支持的需要.
主要方法:
- 一个国际,开放标签,随机临床试验 (ASCOT) 涉及住院的COVID-19患者.
- 参与者在症状出现后的12天内接受了两个单位的CP或标准护理.
- 测量的主要结局是28天内死亡或需要密集呼吸/血管压力器支持的复合结果.
主要成果:
- 该研究在2020年5月至11月期间招募了33名参与者.
- 与标准护理手臂 (23.5%) 相比,CP手臂中较少的参与者 (7%) 达到了主要结果.
- 在CP手臂报告了一个严重的不良事件,被认为与治疗无关.
结论:
- 虽然结果表明CP的潜在益处,但由于外部证据的徒劳,试验被过早停止.
- 小样本规模和早期终止限制了关于CP在COVID-19治疗中的有效性和安全性的最终结论.
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