双酸盐在脏移植接受者与持续的甲状腺上下腺功能障碍症:想两次
Thijs Engelen1, Pieter Evenepoel1,2
1Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium.
Acta clinica Belgica
|November 22, 2025
概括
患有骨质疏松症的脏移植接受者可能不会得到双酸盐的改善,如果持续的副甲状腺功能障碍症导致低酸血症. 矿物质和骨疾病的早期治疗对于有效的骨质疏松症治疗至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 移植患者的骨病是多因素的,模仿各种类型的骨质疏松症.
- 慢性病-矿物质和骨疾病 (CKD-MBD) 是常见的移植后.
研究的目的:
- 为了突出一个骨质疏松症治疗失败的病例在脏移植接受者.
- 识别持续性甲状腺功能障碍症和低酸血作为潜在的原因.
主要方法:
- 一个60岁的女性脏移植接受者患有骨质疏松症的案例介绍.
- 对每年使用佐莱德罗纳特治疗的治疗反应的综述.
- 持续性偏甲状腺功能障碍症和低酸血的诊断评估.
主要成果:
- 患者在5年后没有改善骨矿物质密度 (aBMD).
- 持续性甲状腺功能障碍症和随后的低酸血症被确定为可能的原因.
- 抗吸收疗法可能会掩盖甲状腺功能障碍症,延迟适当的治疗.
结论:
- 在开始使用针对骨的药物之前,控制CKD-MBD是必不可少的.
- 抗吸收剂可以通过掩盖骨表型来复杂化甲状腺功能障碍症的诊断.
- 在患有骨质疏松症的移植接受者中,对甲状腺功能障碍的早期诊断和管理至关重要.
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