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Updated: Jan 6, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

CircAI:与A-to-I RNA编辑相关的CircRNA的综合数据库

Yulan Wang^1,2, Lingxiao Zou¹, Jian Zhao¹

¹Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China.

Database : the journal of biological databases and curation

|November 22, 2025

概括

编辑RNA,一个关键的过程改变RNA,有许多未知的功能,特别是在圆形RNAs (circRNAs). 我们创建了CircAI,这是一个详细介绍circRNA编辑站点的数据库,并预测它们对物种的功能影响.

科学领域:

分子生物学分子生物学
基因组学就是基因组学.
生物信息学是一种生物信息学.

背景情况:

RNA编辑,特别是腺变异因子 (A-to-I) 修改,是一种广泛的转录后事件,具有重要的功能作用.
在哺乳动物中已知有超过200万个A-to-IRNA编辑部位,但它们的功能含义,特别是在非编码区域和循环RNA (circRNAs) 中,仍然在很大程度上未被探索.

研究的目的:

在多种物种的circRNA中全面分析A-to-IRNA编辑部位.
开发一个集中式数据库,CircAI,将circRNA编辑数据与功能预测集成在一起.
为研究circRNAs中RNA编辑的功能后果提供资源.

主要方法:

在八个物种的circRNA中对A-to-I编辑部位进行了深入分析:智人,肌肉肌肉,子子,子子,北欧鼠,Oryctolagus cuniculus,Sus scrofa和Danio rerio.
将收集的数据集成到CircAI数据库中.
在CircAI内部开发功能预测模块,包括编码潜力,miRNA相互作用,二次结构和RNA编辑定量特征位置 (edQTL).

主要成果:

多种 circRNA 编辑数据的识别和编译.
建立CircAI,这是第一个将circRNA编辑信息与功能预测相结合的数据库.
实施用户友好的工具来探索circRNA编辑的预测功能影响.

结论:

CircAI为了解 circRNAs 中RNA 编辑的功能意义提供了宝贵的资源.
该数据库有助于研究circRNA编辑在生物过程和疾病中的作用.
通过CircAI进一步探索circRNA编辑,可以发现新的调节机制.

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Published on: November 14, 2019

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