针对自闭症成年人的自我伤害和自杀行为进行调整的安全计划:单臂可行性试验和外部试点RCT
Jacqui Rodgers1, Nawaraj Bhattarai2, Jane Goodwin1
1Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Public health research (Southampton, England)
|November 22, 2025
概括
自闭症适应安全计划显示出降低自闭症成年人自杀风险的潜力. 需要进一步的研究来证实它们在国家卫生服务机构的有效性.
科学领域:
- 自闭症谱系障碍 自闭症谱系障碍
- 自杀预防 自杀预防
- 心理健康干预 心理健康干预
背景情况:
- 自闭症成年人是英国自杀高风险群体.
- 没有任何预防自杀的干预措施是专门为自闭症患者设计的.
- 安全计划是公认的,具有成本效益的干预措施.
研究的目的:
- 评估自闭症成年人自闭症适应安全计划 (AASPs) 的可行性和可接受性.
- 试点AASPs以确定未来最终试验的可行性.
主要方法:
- 多阶段研究,包括重点小组和可行性试验.
- 根据自闭症成年人,家庭成员和服务提供者的反,对AASP进行了调整.
- 试点随机对照试验 (RCT) 将AASP加常规护理与单独的常规护理进行比较.
- 可行性和可接受性是主要结果,随访时间为1个月和6个月.
主要成果:
- 68%的参与者对AASP感到满意; 41%的人认为它们是可用的.
- 6个月的高保留率 (95%) 和结果措施的高完成率 (>85%).
- 提供AASP的高保真度评级 (94%的治疗成分,91%的坚持).
结论:
- 当灵活实施时,AASP对于自闭症成年人来说是一个潜在的有价值的干预措施.
- 确定RCT的参数可以通过轻微的调整来实现.
- 建议对AASP在NHS服务中的临床和成本效益进行紧急测试.
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