相关实验视频

Updated: Jan 10, 2026

Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions

Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions

Published on: June 13, 2025

在引起的损伤的同时暴露模型中,ursodeoxycholic酸的保护作用

Kemal Kavakli¹, Durmus Hatipoglu¹, Aysegul Bulut²

¹Faculty of Veterinary Medicine, Department of Physiology, Selcuk University, Konya, Türkiye.

Toxicology and industrial health

|November 22, 2025

概括

Ursodeoxycholic 酸 (UDCA) 在老鼠中提供部分保护,防止引起的损伤. UDCA治疗减少了由这种有毒重金属引起的氧化应激和损伤的标志物.

科学领域:

毒理学毒理学毒理学
腎臟病學 (nephrology) 是一種醫學專業.
药理学药理学是指药理学的学科.

背景情况:

(Cd) 是一种有毒的重金属,在脏中积累,造成严重的健康风险.
Ursodeoxycholic 酸 (UDCA),以肝脏应用而闻名,在毒理学研究中表现出抗氧化特性,具有潜在的保护作用.

研究的目的:

在大鼠模型中研究UDCA对引起的损伤的保护作用.
评估UDCA在暴露于后减轻氧化应激和脏病理损伤的能力.

主要方法:

雄性Wistar Albino大鼠被分为对照, (Cd),UDCA和+UDCA组.
是通过腹膜内注射的,而UDCA是在15天内通过胃内注射的.
生物化学标志物 (BUN,肌素,KIM-1,MDA,GSH) 和组织病理变化被评估以评估损伤.

主要成果:

暴露显著增加了血清BUN,肌,KIM-1和MDA水平,同时降低了GSH,表明氧化应激和毒性.
同时使用UDCA显著减轻了这些引起的生化变化.
组织病理学分析显示,+UDCA组与仅组相比,+UDCA组的损伤减少,包括皮质死和管状损伤减少.

结论:

在大鼠中,UDCA显示出对诱导的毒性有部分保护作用.
UDCA减轻了引起的氧化应激,并降低了组织病理损伤的严重程度.
这些发现表明UDCA作为一种治疗剂的潜力,可以抵消重金属诱导的损伤.

关键词:

在KIM-1中,它是KIM-1.和是最重要的元素.脏脏脏是什么?毒性毒性毒性乌尔索多氧胆酸是什么意思

更多相关视频

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

Published on: October 21, 2017

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability

Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability

Published on: June 21, 2015

相关概念视频

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...