相关实验视频

Updated: Jan 10, 2026

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.6K

铜诱导的微质激活涉及PKC/NOX/PARP-1/TRPM2信号通路

Tze Wei Chew1, Nur Zulaikha Mohamad Zahir1, Amir Syahir Amir Hamzah1

  • 1Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia.

Advances in experimental medicine and biology
|November 22, 2025
PubMed
概括

过多的铜 (Cu2+) 通过TRPM2通道激活微质细胞,涉及活性氧物种 (ROS) 和PARP-1. 这项研究阐明了铜诱导的神经炎症的信号通路.

关键词:
铜 (Cu2+) 是一种微质激活的作用氧化应激是一种氧化应激.在 TRPM2 频道中使用 TRPM2 通道.

更多相关视频

Development of an Insert Co-culture System of Two Cellular Types in the Absence of Cell-Cell Contact11:29

Development of an Insert Co-culture System of Two Cellular Types in the Absence of Cell-Cell Contact

Published on: July 17, 2016

28.6K
Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity08:37

Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity

Published on: October 25, 2016

7.4K

相关概念视频

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
9.7K