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Updated: Jan 10, 2026

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测序平台影响细分形积分和累积活产率:一个单中心队列研究

Shun Xiong¹, Jiang Wang^2,3, Tao Fu^2,3

¹Center for Reproductive Medicine, Women and Children's Hospital of Chongqing Medical University, Chongqing, China. xiongshun079@126.com.

Journal of assisted reproduction and genetics

|November 22, 2025

概括

测序平台的选择显著影响了前植入基因测试对形状 (PGT-A) 的结果,影响了细分形状检测和累积活产率 (CLBR). 平台选择是影响PGT-A结果的独立因素.

科学领域:

生殖医学生殖医学
遗传学遗传学是一个
在体外受精过程中受精.

背景情况:

在优化试管婴儿成功方面,对阳积体 (PGT-A) 的植入前遗传检测至关重要.
PGT-A结果的变化可能受到技术因素的影响,包括测序平台.
了解这些技术影响是改善临床结果的关键.

研究的目的:

为了确定不同的测序平台是否会影响PGT-A遗传测试结果.
评估测序平台对PGT-A周期累积活产率 (CLBR) 的影响.

主要方法:

一个回顾性队列研究506个PGT-A周期的女性年龄≤40岁.
循环根据测序平台 (A平台和B平台) 被分为两组.
主要结局:CLBR;次要结局:遗传检测结果 (欧体,无体,细分无体,全染色体无体).

主要成果:

平台A表现出较低的euploidy (49.46%对比55.75%) 和较高的aneuploidy率 (36.92%对比30.73%),这是由增加的细分性形形 (SA) 驱动的.
平台A的基因可转移芽细胞 (GTB) 率较低 (53.68%与61.80%) 和更高的循环取消率 (21.65%与11.86%).
每个活检周期的CLBR与平台B显著更高 (69.87%vs. 60.82%),而平台选择独立地影响了CLBR.

结论:

测序平台的选择显著影响PGT-A遗传测试结果.
在SA检测率和CLBR的平台依赖性变异性影响临床结果.
选择合适的测序平台对于优化PGT-A疗效和活产率至关重要.

关键词:

这就是CLBR.在PGT-A中.细分性积症是指细分性积症.测序平台是一个测序平台.

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