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基于红细胞的猪-a基因突变试验.

Jeffrey C Bemis1, Nikki E Hall2, Stephen D Dertinger2

  • 1Litron Laboratories, Rochester, NY, USA. jbemis@litronlabs.com.

Methods in molecular biology (Clifton, N.J.)
|November 22, 2025
PubMed
概括

猪-a基因突变试验通过分析红细胞表面蛋白质来检测基因毒性. 这种方法对于药物开发期间的临床前安全测试至关重要.

关键词:
内生突变是一种内生突变.红细胞是红细胞.流动细胞计量流动细胞计量基因毒性 基因毒性葡萄糖酸酸氨基 (GPI) 的.高吞吐率的高吞吐量.免疫磁性分离方式猪-一个猪.网状细胞 (Reticulocytes) 是一个细胞.

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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

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In vitro Mutagenesis01:16

In vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.