在接受tACS/CBTp (脑间交流电刺激/精神病认知行为疗法) 与常规药物治疗方案相关的精神分裂患者的治疗改善:试点,随机,单盲试验的协议
Felicia Iftene1, Adriana Farcas2, Simon O'Brien1
1Queen's University, Department of Psychiatry, Kingston, Ontario, Canada/Providence Care Mental Health Services, Kingston, Ontario, Canada., 752, King St West, Kingston, CA.
JMIR research protocols
|November 22, 2025
概括
这项研究调查了跨交替电流刺激 (tACS) 是否可以增强精神病的认知行为疗法 (CBTp) 在精神分裂症患者. 早期的结果表明,tACS可能会改善结果,并可能产生性别特异性的影响.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 精神分裂症的特征是乱的马频率同步,这对认知功能至关重要.
- 目前的治疗方法包括药物治疗和CBTp;本研究探讨用tACS增强CBTp.
- tACS旨在引入马振荡,潜在地改善认知准备和治疗参与.
研究的目的:
- 评估是否将tACS添加到CBTp可以提高精神分裂症患者的认知准备和治疗参与度.
- 评估tACS增强的CBTp对功能水平的影响.
- 为了确定对tACS和CBTp的治疗反应是否与性别有关.
主要方法:
- 试点,前性,随机化,重复测量,单盲研究.
- 28名参与者被随机分配到tACS/CBTp或假tACS/CBTp组16周.
- 主要结局包括EEG,PANSS,NSA-16和CFS,使用重复测量ANOVA进行分析.
主要成果:
- 初步招生显示有15名参与者,其中12名正在进行中.
- 预期:tACS/CBTp将在心理社会测试和EEG活动中比假的更好地改善.
- 假设:治疗反应可能是性别特定的;基线HRV可能预测症状改善.
结论:
- 这项研究旨在提高精神分裂症治疗效率和患者的生活质量.
- 有可能降低与精神分裂症相关的复发率和医疗保健费用.
- 对tACS作为精神分裂症辅助疗法的进一步研究是有必要的.
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