在挪威和瑞典的SARS-CoV-2疫苗接种和肌肉炎
Rickard Ljung1,2, Nicklas Pihlström1,2, Jesper Dahl3
1Pharmacoepidemiology and Analyses Department, Swedish Medical Products Agency, Uppsala, Sweden.
Rheumatology (Oxford, England)
|November 22, 2025
概括
这项研究发现,mRNA或腺病毒载体疫苗接种SARS-CoV-2疫苗后,肌肉炎的风险没有增加. 这项研究分析了超过1300万个人的情况,证实了疫苗对肌肉炎的安全性.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- 肌肉炎是一种罕见的炎症状况,影响肌肉.
- 了解SARS-CoV-2疫苗的潜在副作用对于公共卫生至关重要.
- 在全球范围内,mRNA和腺病毒载体疫苗都被广泛使用.
研究的目的:
- 为了调查接收SARS-CoV-2疫苗后发展肌肉炎的风险.
- 为了比较mRNA和腺病毒载体疫苗接种者和未接种疫苗的个人之间的风险.
主要方法:
- 在挪威和瑞典进行基于人口的队列研究.
- 涉及超过1300万个12岁及以上的个人.
- 使用波桑回归来分析接种疫苗和未接种疫苗期间的肌肉炎发病率,调整为混因素.
主要成果:
- 在未接种疫苗的人群中观察到101例肌肉炎事件和mRNA疫苗接种后180天内99例事件.
- 在腺病毒载体疫苗接种后180天内观察到13例肌肉炎事件.
- 针对mRNA和腺病毒载体疫苗的调整后发病率比率 (IRR) 分别为0.84 (95% CI,0.63-1.11) 和1.31 (95% CI,0.72-2.36),表明没有显著增加的风险.
结论:
- 没有证据表明SARS-CoV-2疫苗接种后肌肉炎的风险增加.
- 这一发现适用于mRNA和腺病毒载体疫苗类型.
- 这项研究加强了COVID-19疫苗关于肌肉炎的安全概况.
关键词:
这就是SARS-CoV-2病毒.药物不良反应 药物不良反应自身免疫性疾病 自身免疫性疾病它们是mRNARNA.骨髓病变是一种神经病变.肌肉性肌肉性炎症 肌肉性肌肉炎监控监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督疫苗 疫苗 疫苗 疫苗更多相关视频
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