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一种基于氧化氨酸的pH敏感智能水凝,具有协同抗菌特性

Zimin Wan¹, Yifan Zhao¹, Xueqiong Zhang¹

¹School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China.

Colloids and surfaces. B, Biointerfaces

|November 22, 2025

概括

这项研究开发了一种pH响应的水凝,用于联合输送托布拉米辛和柏柏林,以对抗伤口感染. 智能水凝增强了抗生素的有效性,并消除了细菌,提供了一个有前途的伤口愈合策略.

科学领域:

生物材料科学生物材料科学
传染性疾病传染性疾病
药物输送系统药物输送系统

背景情况:

伤口感染是一个重大的临床问题,阻碍愈合,并冒着慢性或危及生命的疾病的风险.
目前的治疗方法面临着副作用和对抗细菌感染的有效性方面的挑战.

研究的目的:

设计一个响应pH的智能水凝,可同时提供托布拉米辛 (TOB) 和柏柏林 (BBR).
增强抗菌活性,减少抗生素在伤口感染中的副作用.

主要方法:

制造一种适应pH的水凝,能够同时提供TOB和BBR.
在模拟炎症环境 (pH 5.0) 中评估药物释放特征.
评估水凝的特性,包括胀,可注射性,生物相容性和自我愈合.
抗菌试验以确定TOB和BBR的协同作用.

主要成果:

在pH值为5.0的情况下,水凝在48小时内显著释放TOB (72.12%) 和BBR (93.11%) .
水凝表现出优异的膨胀,可注射性,生物相容性和自我愈合特性.
柏柏林增强了托布拉米的活性,显示出有效根除细菌的协同效应.

结论:

响应pH的智能水凝为有效的抗生素和辅助剂联合递送提供了一个可行的平台.
这种双重药物输送系统显示出治疗细菌性伤口感染的巨大潜力.
协同作用增强治疗结果,并最大限度地减少与抗生素相关的副作用.

关键词:

抗菌水凝是一种抗菌水凝.氧化氨酸是氧化氨酸的一种.对于PH敏感的物质.智能水凝是一种智能水凝.

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