Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Protein and Protein Structure02:15

Protein and Protein Structure

86.6K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
86.6K
Globular Proteins01:27

Globular Proteins

9.7K
In organisms, proteins are the most abundant macromolecules. They act as the building blocks of life and play various crucial roles in the body. Proteins can be broadly classified into two distinct subtypes based on their shape and solubilities: globular proteins and fibrous proteins.
Globular proteins serve many important physiological functions, such as acting as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be soluble in the aqueous...
9.7K
Protein Organization01:24

Protein Organization

9.0K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
9.0K
Protein Organization01:13

Protein Organization

155.6K
Overview
155.6K
Protein Folding01:22

Protein Folding

125.9K
Overview
125.9K
Protein Folding01:25

Protein Folding

11.0K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
11.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Quantifying the Uncertainty of Molecular Dynamics Simulations: Good-Turing Statistics Revisited.

Journal of computational chemistry·2026
Same author

The Curious Case of A31P, a Topology-Switching Mutant of the Repressor of Primer Protein: A Molecular Dynamics Study of Its Folding and Misfolding.

Journal of chemical information and modeling·2024
Same author

A proof-of-concept study of the secondary structure of influenza A, B M2 and MERS- and SARS-CoV E transmembrane peptides using folding molecular dynamics simulations in a membrane mimetic solvent.

Physical chemistry chemical physics : PCCP·2022
Same author

Folding molecular dynamics simulation of T-peptide, a HIV viral entry inhibitor: Structure, dynamics, and comparison with the experimental data.

Journal of computational chemistry·2022
Same author

A molecular dynamics simulation study on the propensity of Asn-Gly-containing heptapeptides towards β-turn structures: Comparison with ab initio quantum mechanical calculations.

PloS one·2020
Same author

Catalytic activity regulation through post-translational modification: the expanding universe of protein diversity.

Advances in protein chemistry and structural biology·2020

相关实验视频

Updated: Jan 10, 2026

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
09:25

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments

Published on: November 1, 2024

2.6K

蛋白质中的原子密度分布:结构和功能上的影响.

Sotirios Touliopoulos1, Nicholas M Glykos1

  • 1Department of Molecular Biology and Genetics, Democritus University of Thrace, University Campus, 68100, Alexandroupolis, Greece.

Journal of molecular graphics & modelling
|November 22, 2025
PubMed
概括

原子包装显著影响蛋白质的稳定性和功能. 这项研究分析了21,255个蛋白质结构,揭示了不同的包装组和影响原子密度的因素,如蛋白质大小和类型.

科学领域:

  • 结构生物学 结构生物学
  • 生物物理学的生物物理.
  • 计算生物学 计算生物学

背景情况:

  • 原子包装对于蛋白质结构,稳定性,进化和功能至关重要.
  • 蛋白质包装不均,有更密集的核心和更松散的表面,可以受到内部空洞的影响.
  • 衡量蛋白质包装质量的现有方法存在局限性.

研究的目的:

  • 分析蛋白质结构的大型数据集中的原子密度分布.
  • 根据它们的包装特征来识别不同的蛋白质组.
  • 研究影响原子包装的因素,包括蛋白质大小,类型和稳定性指标.

主要方法:

  • 从21,255个非冗余蛋白质结构中分析原子密度分布.
  • 包括原子和溶解用于体外表现.
  • 层次聚类以组合具有相似原子密度模式的蛋白质.

主要成果:

  • 在蛋白质结构中观察到原子密度分布的统计学上显著差异.
  • 层次聚类确定了不同的群体,其中一些与特定结构 (卷轴-卷轴,细胞染色体) 或分类家族 (水解酶,转移酶) 相关.
  • 较大的蛋白质的密度范围较窄,但包装较松散;包装密度与水分子和B因子等稳定性指标相关.
关键词:
集群结构是指集群结构.疏水性核心是一种疏水性核心.包装密度 包装密度 包装密度蛋白质结构 蛋白质结构蛋白质结构/功能关系 蛋白质结构/功能关系

更多相关视频

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.0K
Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
07:33

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry

Published on: October 15, 2018

14.9K

相关实验视频

Last Updated: Jan 10, 2026

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
09:25

Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments

Published on: November 1, 2024

2.6K
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.0K
Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
07:33

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry

Published on: October 15, 2018

14.9K

结论:

  • 蛋白质结构表现出各种各样的原子包装行为,超出了简单的核心-表面差异.
  • 特定的结构图案和蛋白质家族与特有的包装密度有关.
  • 原子包装与蛋白质大小和稳定性密切相关,为蛋白质生物物理学提供了洞察力.