在印度尼西亚西爪的肉养殖场对抗菌素使用和抗菌素耐药性的干预措施的纵向评估,印度尼西亚西爪
Rianna Anwar Sani1, Annisa Rachmawati2, Sunandar Sunandar2
1Division of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.
Poultry science
|November 22, 2025
概括
针对性的干预措施显示,印尼肉养殖场的胆固醇使用量显著减少了92.6%,但总体而言,大肠杆菌的抗菌剂使用和耐药性并没有显著下降. 需要进一步的策略来有效地减轻抗菌素耐药性 (AMR).
科学领域:
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 抗菌素耐药性 (AMR) 是一个日益增长的全球公共卫生问题.
- 在生产食品的动物中减少抗菌素使用 (AMU) 对于AMR缓解至关重要.
- 小型和中型肉养殖场有助于AMU和AMR动态.
研究的目的:
- 评估针对性干预措施在印尼西爪的肉养殖场对AMU和AMR的影响.
- 评估抗微生物药物使用模式的变化和开始性大肠杆菌的耐药性水平.
- 为了确定与肉生产中的AMU相关的风险因素.
主要方法:
- 纵向研究 (2019-2023) 采用来自14个农场 (55个周期) 和19个农场 (98个周期) 的干预前后数据.
- 根据每30天周期的治疗频率评估AMU;使用对大肠杆菌的最小抑制度 (MIC) 值分析AMR.
- 统计分析包括AMU的层次贝叶斯负二项回归和AMR的贝叶斯高斯线性模型,控制死亡率,生物安全性和季节性.
主要成果:
- 总体而言,AMU的治疗频率从0.4降至0.3 (11至9天/周期),但干预效应在统计学上并不显著.
- 观察到胆固醇使用量显著下降92.6%,这可能是由于国家禁令.
- 在干预后的14种测试抗微生物药物中,没有观察到大肠杆菌非野生类型表型 (耐药性) 的显着下降.
结论:
- 有针对性的干预措施导致素使用量大幅减少,受国家政策的影响.
- 大肠杆菌中的AMU和AMR总体水平没有显著下降,这表明AMR缓解策略的复杂性.
- 需要进一步的研究来开发和验证有效的AMU减少策略,以对抗肉养殖中的AMR.
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