HLA-B27调节肠道微生物群的组成,并驱动一种促炎性肠道微生态
Tao Zhang1, Si-Yu Chen1, Cong Zhang1
1Department of Clinical Immunology, Xijing Hospital and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Air Force Medical University, Xi'an 710032, China.
Human immunology
|November 22, 2025
概括
人类白细胞抗原B27 (HLA-B27) 显著改变肠道微生物群,促进自身免疫性疾病的炎症. 这种遗传因素重塑了肠道微生物生态系统,提供了潜在的治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 诸如脊椎关节炎 (SpA),类风湿性关节炎 (RA) 和炎症性肠病 (IBD) 等自身免疫性疾病涉及遗传倾向和肠道微生物群失调.
- 宿主基因影响肠道微生物群驱动炎症疾病的确切机制尚未完全理解.
研究的目的:
- 研究人类白细胞抗原B27 (HLA-B27) 对肠道微生物组成的影响.
- 探索HLA-B27和与HLA-B27相关的自身免疫性炎症疾病之间的关联.
- 阐明HLA-B27在重新塑造肠道微生物群的机制性作用,使其进入促炎状态.
主要方法:
- 在小鼠模型中HLA-B27/β2M的表达.
- 使用多omics方法分析肠道微生物的组成和功能.
- 代谢分析,以评估肠道代谢物质的变化.
主要成果:
- HLA-B27/β2M表达显著改变了肠道微生物的多样性,有利于格拉姆阴性细菌而不是格拉姆阳性细菌.
- 观察到肠道代谢特征的深刻变化,前列腺素增加,抗炎代谢物减少.
- 这些变化集体地将肠道微生物群体转移到一种促炎状态.
结论:
- 遗传因素,以HLA-B27为例,可以显著重塑肠道微生物群的组成.
- HLA-B27将肠道微生物生态系统驱动到促炎状态,从而导致自身免疫性病原体的产生.
- 这项研究为识别HLA-B27相关炎症性疾病中的微生物点提供了基础.
相关概念视频
Irritable Bowel Syndrome I: Introduction
899
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
899
Chronic Bowel Disorders: Introduction
735
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
735
Inflammatory Bowel Disease I: Ulcerative Colitis
876
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
876
Bacterial Flora of the Large Intestine
1.5K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.5K
Anatomy of the Intestines
86.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.6K


