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菲莫斯治疗和尿路感染在男性婴儿中复发的风险:系统性审查
Tatjana Heisinger-Heidler1, Rachel Shannon2, Theresa Meyer2
1Division of Urology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.
Urology
|November 22, 2025
概括
割礼和局部皮质类固醇可以降低男性婴儿复发性尿路感染 (rUTI) 的风险. 然而,目前的证据有限,需要进一步的高质量研究来证实这些发现.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 预防传染病 预防传染病
- 系统审查方法论 系统审查方法论
背景情况:
- 皮前皮的疾病 - - 菲莫斯 (Phimosis) 与男性婴儿复发性尿路感染 (rUTI) 的风险增加有关.
- 症的治疗选择包括割礼和局部皮质类固醇,但它们在预防RUTI方面的有效性尚未得到充分证实.
研究的目的:
- 系统地审查现有的关于割礼和局部皮质类固醇治疗瘤治疗在预防男婴RUTI的有效性的文献.
主要方法:
- 在多个数据库 (PubMed,Embase,Cochrane图书馆等) 进行了全面的系统审查. 在2024年9月之前.
- 包括的研究重点是初级数据,涉及经过割礼或局部皮质类固醇治疗后的尿路感染率,在有尿路感染史的婴儿中.
- 质量评估和偏差风险使用Joanna Briggs研究所的批判性评估工具进行了评估.
主要成果:
- 只有4项研究符合纳入标准 (2项是割礼,2项是局部皮质类固醇).
- 割礼术后没有显示任何rUTI病例,与未割礼婴儿的发病率相比 (31%和11%).
- 局部皮质类固醇显示出有希望的结果,治疗婴儿的RUTI为0,未治疗婴儿为16%,与瓦斯林 (21%) 相比,瘤分辨率更高 (90%).
结论:
- 割礼和局部皮质类固醇似乎有可能降低男性婴儿的RUTI风险.
- 目前的证据基础有限,不足以进行元分析.
- 需要高质量的研究来确定这些干预措施对rUTI的预防作用.
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