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Updated: Jan 10, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

可翻译的圆形RNA:机制,功能和临床应用

Zhenxing Song¹, Min Zhou², Jiamei Lin¹

¹School of Life Sciences, Chongqing University, Chongqing, China.

International journal of biological macromolecules

|November 22, 2025

概括

循环RNAs (circRNAs) 可以独立于通常的mRNA封顶转化为蛋白质. 这些circRNA编码的蛋白质是基因调节和人类疾病的关键参与者,具有治疗潜力.

科学领域:

分子生物学分子生物学
遗传学是一个遗传学.
生物化学生物化学

背景情况:

循环RNA (circRNAs) 具有独特的翻译能力,与线性mRNA不同.
它们的性封闭结构使得它们能够独立于帽子的翻译启动.
环RNA编码的蛋白质被认为是人类疾病的关键调节者.

研究的目的:

系统地审查circRNAs中cap独立翻译启动的机制.
总结可翻译circRNAs在各种疾病中的作用和分子机制.
突出circRNAs在基因疗法和疫苗开发中的治疗潜力.

主要方法:

审查关于circRNA翻译的现有文献.
分析涉及circRNA转化中的cis调节元素,转作用因子和RNA结构.
综合了关于circRNA编码蛋白在疾病发病过程中的作用的数据.

主要成果:

鉴定了circRNAs的cap-independent翻译启动的多种机制.
详细介绍了circRNA编码的蛋白质在疾病发病和进展中的参与.
证明了circRNAs在基因表达中的重要调节作用.

结论:

翻译性circRNAs是基因表达的关键调节者,在人类疾病中起着重要作用.
环RNAs独特的转化机制为基于RNA的疗法提供了有前途的机会.
由于它们的多功能潜力,circRNAs代表了当前生物医学研究的主要焦点.

关键词:

基因治疗是一种基因疗法.高阶RNA结构的结构.交互作用的因素.可以翻译的circRNA 疫苗的研发工作正在进行中.有 cis 作用的 RNA 元素.

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Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

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