通过IL-1β/TRPV1通路调节缓解过敏性鼻炎的HDRSD的多年阐明
Yunong Li1, Jianing Yang2, Ruobai Liu2
1Department of Traditional Chinese Medicine, Yanbian University Medicine College, Yanji, 133002, PR China; Jilin Key Laboratory for Immune and Targeting Research on Common Allergic Diseases, Yanbian University, Yanji, 133002, PR China.
Journal of ethnopharmacology
|November 22, 2025
概括
汉杜鲁雷沙奥 (HDRSD) 通过向IL-1β/TRPV1通路,有效治疗过敏性鼻炎 (AR). 这种韩国传统医药可以减少炎症和线粒体损伤,为AR提供了一种新的治疗方法.
科学领域:
- 综合医学是一个整体医学.
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
- 韩国传统医学 韩国传统医学
背景情况:
- 韩二重沙子 (HDRSD) 是一种韩国传统药物,用于治疗感冒模式过敏性鼻炎 (AR).
- 高强度应激障碍解决了肺 - - 脏奇阳缺乏症,这是AR易感性的关键因素.
- 这项研究旨在通过民族药理学和网络药理学阐明HDDRSD在AR治疗中的多组件,多目标,多途径机制.
研究的目的:
- 系统地识别AR治疗中HDDRSD的活性成分,分子标和机制.
- 通过全面的体内和体外实验方法来验证发现.
主要方法:
- 雇佣了网络药理学,分子对接,转录组测序,代谢学,西方斑点和免疫光学.
- 使用HDM诱导的AR小鼠模型进行体内研究 (转录组学,ELISA,HE染色等). ) 的情况.
- 用人鼻上皮细胞 (HNEpCs) 在体外验证IL-1β/TRPV1通路.
主要成果:
- 在AR小鼠中,HDRSD显著降低了促炎性细胞因子 (TNF-α,IL-4,IL-5,IL-6,IL-13) 和乙素透.
- 网络药理学确定IL-6和IL-1β是核心点; 西方布洛特证实IL-6,IL-1β,TRPV1和NLRP3的蛋白质水平降低.
- HDRSD调节了脂质代谢途径,并且在机械上降低了IL-1β的调节,抑制了IL-1β/TRPV1相互作用,减少了Ca2+的流入,并缓解了HNEpCs中的线粒体损伤和亡.
结论:
- 通过IL-1β/TRPV1信号通路减少线粒体损伤,HDRSD的活性成分可以减轻AR.
- 这些发现支持HDRSD作为AR的有效治疗方法,强调其多目标和多途径的治疗作用.
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