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相关实验视频

Updated: Jan 10, 2026

Method of Studying Palatal Fusion using Static Organ Culture
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在 palatal rugae 发育中的衰老.

Finsa Tisna Sari1, Maiko Kawasaki1, Katsushige Kawasaki2

  • 1Division of Oral Anatomy, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Journal of oral biosciences
|November 22, 2025
PubMed
概括

在 palatal rugae 发育过程中存在着类似衰老的细胞,它们独立于 p21 激活. 这一细胞过程,标志着与衰老相关的β-galactosidase活性,是由老化药物调节的.

关键词:
鼠标 鼠标是一个鼠标.地区码 地区码 地区码鲁加的发展.衰老是一种衰老.在p2121中,

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科学领域:

  • 发展生物学 发展生物学
  • 细胞衰老 细胞衰老

背景情况:

  • 周期性模式是器官之间保存的发育机制.
  • 哺乳动物中的口腔细菌可以作为研究周期性模式的模型.
  • 了解 palatal rugae 形成的细胞基础至关重要.

研究的目的:

  • 为了研究细胞衰老在 palatal rugae 发育中的作用.
  • 在这个过程中识别衰老背后的分子机制.

主要方法:

  • 在野生类型小鼠胚胎中分析与衰老相关的β-galactosidase (SA-β-gal) 活性.
  • 在 palatal rugae 发育过程中检查 IL-6 和 p21 表达.
  • 在p21缺乏的小鼠中研究SA-β-gal活性.
  • 对SA-β-gal活性的老化药物疗效的评估.

主要成果:

  • 在发育中的 palatal rugae placodes (E12-14) 中检测到SA-β-gal活性.
  • IL-6和p21表达与SA-β-gal活性相关.
  • 衰老标志物减少了E16,与巨细胞标志物表达一致.
  • 在p21缺乏的小鼠中,SA-β-gal活性持续存在,并且被老化药物降低.

结论:

  • 类似衰老的细胞参与了 palatal rugae 的发展.
  • 这些细胞通过p21独立的途径被激活.
  • 在 palatal rugae 发育过程中的衰老可以通过老化干预措施来准.