基于微化-κ-carrageenan的瞬时凝形成微囊,用于灭苦味,生物灵感来自激情果种子
Jiao Song1, Linjie Tian2, Shuyu Deng2
1State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China; Pharmacy department, Leshan Traditional Chinese Medicine Hospital, Leshan, 641000, PR China.
Carbohydrate polymers
|November 22, 2025
概括
使用Panax Notoginseng Saponins,橄油和 κ-carrageenan 开发了可以灭苦味的瞬时凝形成的微囊. 这些微囊显著降低了苦味,改善了对苦药的药物服药性.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 传统的固体药物配方往往由于苦味而受到糟糕的味道影响.
- 低剂量药物服药是治疗用苦味药物治疗患者的一个重大挑战.
研究的目的:
- 为了发展苦味,灭即时凝形成的微囊,以掩盖Panax Notoginseng Saponins (PNS) 的苦味.
- 通过创新的微封装,提高苦药的口感,提高药物适应性.
主要方法:
- 使用干涂技术制造了Panax Notoginseng Saponins-olive oil-κ-carrageenan (PNS-OLI-CAR) 的微囊.
- 优化了PNS:橄油:微缩k-carrageenan的比例 (1:0.025:0.6) 和封装时间 (15分钟).
- 评估了苦味掩盖,即时凝形成特性,分散性,颗粒大小,药物加载和封装效率.
主要成果:
- 与PNS相比,PNS-OLI-CAR微囊显示了与PNS相比,苦味和苦味的显著减少 (超过60%).
- 在70°C时,在10秒内实现了优异的即时凝形成和水中的分散性.
- 获得了大约40微米的颗粒大小,具有高药物负载 (59.0%) 和封装效率 (94.5%).
结论:
- 立即形成凝的微囊具有仿生结构和双重苦味抑制机制 (物理屏蔽和静电感应).
- 这种新的微封装方法有效地掩盖了药物的苦味,提供了一种有希望的策略,以提高患者的药物服药性.
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