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德拉科塞法卢姆 (Dracocephalum heterophyllum Benth) 的总黄可以通过减轻细胞死亡的不同模式来保护冠状动脉微血管功能障碍

Wenjing Yang¹, Wen He², Sijing Liu¹

¹College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, P. R. China.

Scientific reports

|November 22, 2025

概括

德拉科塞法异构本 (DHBF) 的黄酸在治疗高血压引起的冠状动脉微血管功能障碍 (CMD) 和心肌损伤方面表现有前途. 通过调节关键分子通路,DHBF改善心脏功能并减少细胞死亡.

科学领域:

心血管研究研究心血管研究
药理学药理学是指药理学的学科.
传统医学的传统医学.

背景情况:

冠状动脉微血管功能障碍 (CMD) 是心血管事件的重要危险因素,目标治疗有限.
德拉科塞法 (Dracocephalum heterophyllum Benth,DHB) 黄 (DHBF) 是治疗高血压的传统药物,但它们对CMD的影响尚不清楚.

研究的目的:

研究DHBF对高血压引起的CMD和心肌损伤的治疗作用.
阐明DHBF作用的潜在分子机制.

主要方法:

使用UPLC-Q-TOF-MS.识别了可吸收血清的DHBF组件.
利用网络药理学来预测治疗途径.
在自发高血压大鼠 (SHR) 中评估了DHBF效应,使用心声学,组织病理学,ELISA,qRT-PCR,蛋白质组学,免疫光学和西部涂抹.

主要成果:

在SHR中,DHBF治疗改善了CMD症状,心脏功能,并减少了心肌损伤和原沉积.
DHBF调节血清生物标志物 (ANP,BNP,LDH,CK),减弱氧化应激,并减少炎症类细胞因子.
蛋白质组分析揭示了DHBF在与亡相关的途径中的丰富,通过P-STAT3/STAT3信号通路调节心肌细胞亡,亡和亡.

结论:

DHBF对高血压诱导的CMD和心肌损伤具有显著的保护作用.
通过双重调节细胞死亡途径,DHBF通过改善微血管功能和促进心肌细胞存活来起作用.
DHBF显示出作为治疗高血压相关心血管并发症的治疗剂的潜力.

关键词:

龙头 (Dracocephalum) 异构 (Benth) 是一个类型.冠状动脉微血管功能障碍冠状动脉微血管功能障碍黄类化合物黄类化合物在高血压的高血压.心肌损伤的原因是心肌损伤.

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