原发性血栓微血管病变的眼部表现:一个描述性的系统性综述
Mohammed Baker1, Motasem Ayoub2, Toleen Ghosheh1
1Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
BMC ophthalmology
|November 22, 2025
概括
主要的血栓微血管病变 (TMAs),包括TTP和HUS,可以导致严重的眼睛问题. 这项研究确定了常见的眼部表现,如视网膜出血和Purtscher类视网膜病变,有助于及时检测和管理.
科学领域:
- 眼科医生 眼科 眼科
- 血液学 血液学 血液学
- 内部医学 内部医学
背景情况:
- 主要的血栓性微血管病变 (TMA),包括血栓性血栓性缺血性紫外线 (TTP) 和血液溶解性尿素综合征 (HUS),是具有潜在眼部影响的全身性疾病.
- 早期发现和管理与初级TMA相关的眼部症状对于患者的治疗结果至关重要.
- 本研究的重点是确定由初级HUS和TTP的系统性影响导致的眼部表现的频谱.
研究的目的:
- 系统地识别和描述与原发性血栓性血栓性缺血性紫外线 (TTP) 和血清性尿素综合征 (HUS) 相关的眼部表现.
- 为了提供对需要注意的眼部症状的全面概述,在被诊断为初级TMAs的患者.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中进行了全面的文献搜索,截至2024年3月.
- 包括的研究包括病例报告,病例系列和回顾性审查,详细介绍了初级HUS或TTP中的眼部表现.
- 排除标准包括实验研究,非英语出版物,二次TMA,怀孕,眼部创伤/手术和混杂的并发症.
主要成果:
- 该评论分析了37项涉及58名患者的研究,平均年龄为18.87岁.
- 最常见的眼部发现包括视网膜出血 (25.86%),Purtscher类视网膜病变 (24.13%),视网膜脱落 (20.68%) 和视觉盘变化 (18.96%).
- 其他值得注意的表现是毛细管在光素血管图 (FFA) (13.79%) 和孤立的棉羊毛斑点 (12.06%) 的毛细管不 perfusion.
结论:
- 视网膜出血,Purtscher-like视网膜病变,视网膜脱落,视盘变化,毛细血管不 perfusion,和棉羊毛斑点是主要的TMAs的眼睛表现.
- 识别这些眼部症状对于初级TMA患者的有效检测和管理至关重要.
- 建议进行进一步的研究,以制定预防性策略,在患有初级TMA的患者中预防这些眼部连续症.
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