妊娠和孕期糖尿病的营养和炎症指数:强调控制营养状况 (CONUT) 评分
Mustafa Rasit Ozler1, Erkan Saglam2, Serenat Yalcin3
1Department of Obstetrics and Gynecology, Division of Perinatology, , Bursa City Hospital, Bursa, Turkey. m.rasitozler@gmail.com.
BMC pregnancy and childbirth
|November 22, 2025
概括
在孕期糖尿病中,营养和炎症标志物比孕期糖尿病更容易受到干扰. 控制营养状况 (CONUT) 评分和炎症指数可以帮助预测糖尿病怀孕中不良产周结果.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 孕期糖尿病 (GDM) 和孕期糖尿病 (PGDM) 是怀孕期间的重要问题.
- 营养状况和炎症在怀孕结果中起着至关重要的作用.
- 早期识别有风险的怀孕对于改善母亲和胎儿健康至关重要.
研究的目的:
- 为了比较GDM和PGDM中营养和炎症指数的预后值.
- 评估这些指数与周产期不良结果之间的关联.
- 确定可靠的生物标志物,用于糖尿病怀孕的风险分层.
主要方法:
- 280名孕妇 (90名GDM,80名PGDM,110名对照) 的回顾性研究.
- 使用控制营养状况 (CONUT) 和预后营养指数 (PNI) 评分来评估营养状况.
- 计算炎症指数 (NLR,SII,SIRI,PIV) 和分析周产期结局 (早产,新生儿重症监护室入院,综合不良周产期结局 - CAPO).
主要成果:
- 与GDM和对照组相比,PGDM组显示出明显更高的CONUT分数和较低的PNI分数.
- 在PGDM中观察到炎症标志物 (NLR,SII,SIRI,PIV) 的升高.
- 对于糖尿病怀孕,CONUT评分显示出强大的区分能力 (AUC=0.787);较高的CONUT和炎症评分与增加的不良周产期结局相关.
结论:
- 营养和炎症障碍在PGDM中比GDM更为明显.
- 康分数和炎症指数对于糖尿病怀孕的早期风险分层有价值.
- 整合这些标志物可能会改善围产期结果,特别是在高风险的PGDM病例中.
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