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在中国汉族人群中,研究了因特鲁金10基因与吸烟与食道癌症风险相互作用的相关性分析

Jiamin Zhu¹, Baixia Yang², Feng Ni²

¹Department of Oncology, the Affiliated Jiangyin Hospital of Nantong University, Jiangyin, 214400, Jiangsu Province, China.

World journal of surgical oncology

|November 22, 2025

概括

某些互白素-10 (IL-10) 基因单核酸多态 (SNP) 会增加食道癌 (EC) 的风险. rs1800896 SNP与吸烟有显著的相互作用,在汉族人群中增加了EC风险.

科学领域:

遗传学和基因组学遗传学和基因组学
癌症流行病学癌症流行病学
分子生物学分子生物学

背景情况:

食道癌 (EC) 是一个重要的全球健康问题.
遗传易感性,包括互白素-10 (IL-10) 基因的变异,在EC发育中起作用.
吸烟和饮酒等环境因素是EC的确定的风险因素.

研究的目的:

研究IL-10基因中的四种单核酸多态 (SNPs) 与食道癌 (EC) 风险之间的关联.
评估潜在的基因环境相互作用,特别是IL-10SNP与吸烟或饮酒之间的相互作用,与EC风险相关.
分析中国汉族人口中的这些关联.

主要方法:

进行了四个IL-10基因SNP的基因定型.
评估了哈迪 - 韦恩伯格平衡 (HWE).
使用后勤回归分析来确定SNP与EC风险之间的关联.
一般化多因素维度减小 (GMDR) 用于识别基因-基因和基因-环境相互作用.

主要成果:

rs1800872-A等位基因与EC风险增加显著相关 (OR=1.74,95% CI:1.28-2.25).
rs1800896-A基因基因也显示出与EC风险升高的显著关联 (OR=1.65,95% CI:1.28-2.06).
检测到rs1800896SNP和吸烟之间存在显著的相互作用,携带rs1800896-GA/AA基因型的吸烟者表现出最高的EC风险 (OR=3.76,95%CI:1.71-5.83).

结论:

IL-10基因的特定基因,即rs1800872-A和rs1800896-A,与食道癌的风险增加有关.
rs1800896 SNP与吸烟之间的显著相互作用显著改变了EC风险.
这些发现突出了食道癌症病因学中遗传倾向和环境暴露的综合影响.

关键词:

饮酒饮酒饮酒饮酒饮酒食道癌是食道癌的一个类型.互动互动互动介质蛋白- 10 介质蛋白- 10 介质蛋白单个核酸的多态性.吸烟吸烟吸烟吸烟

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