埃塞俄比亚东北部Debre Berhan镇成年人口的凝血参数参考区间
Amanuel Kelem1, Getabalew Engidaye2, Bedasa Addisu2
1Department of Medical Laboratory Sciences, Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia. amanuelkelem@gmail.com.
Thrombosis journal
|November 22, 2025
概括
这项研究确定了埃塞俄比亚德布雷·贝尔汉 (Debre Berhan) 的成年人的局部凝血参考间隔. 这些发现突出了前列红蛋白时间和国际正常化比率的性别特异性差异,这对于准确的诊断至关重要.
科学领域:
- 临床生物化学 临床生物化学
- 血液学 血液学 血液学
- 公共卫生 公共卫生
背景情况:
- 准确的凝血参数对于诊断出血和血栓性疾病至关重要.
- 现有的参考间隔在不同种群中差异很大.
- 需要局部化间隔来解决遗传,环境和人口变化的问题.
研究的目的:
- 为了在埃塞俄比亚东北部的Debre Berhan,为健康成年人建立局部凝血参考间隔.
- 解决临床实践中对非局部凝血值的依赖问题.
- 为了研究凝血参数的潜在性别特异性差异.
主要方法:
- 一项基于社区的横截面研究,涉及240名健康成年人 (120名男性,120名女性) 在Debre Berhan.
- 面对面采访,使用预先测试的人口统计数据收集问卷.
- 使用Sysmex CA-104分析仪分析静脉血液的前列血时间 (PT),国际正常化比率 (INR) 和激活的部分血栓形成时间 (aPTT).
主要成果:
- 建立了95%的参考间隔:PT (8.5-13.0秒),INR (0.7-1.1秒),aPTT (21.6-37.9秒). 在此间间隔内,我们可以测量出:
- 与女性 (p < 0.001) 相比,男性的中位数PT (10.4秒比9.8秒) 和INR (0.9比0.84) 显著更高.
- 在PT和INR中性别差异的统计学意义得到证实 (p=0.0006).
结论:
- 在Debre Berhan,特定于人群的凝血参考间隔对于准确的诊断和患者安全至关重要.
- 在PT和INR中观察到的性别差异需要性别特定的参考间隔来改善临床决策.
- 采用局部和性别特定的间隔可以防止对凝血测试结果的误解.
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