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Updated: Jan 10, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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探索SRPK1的结构动力学,通过分子建模技术识别具有竞争力的抑制剂

Shreya Mukherjee1, Abhishek Bera1, Niladri Patra1

  • 1Department of Chemistry and Chemical Biology, Indian Institute of Technology (ISM), Dhanbad, Dhanbad, 826004, India.

Chemphyschem : a European journal of chemical physics and physical chemistry
|November 23, 2025
PubMed
概括

这项研究确定了一种强大的新抑制剂,CNP0199214,向氨酸蛋白蛋白激酶1 (SRPK1) 以对抗癌症. 计算方法揭示了其强大的结合亲和力,为开发新型抗癌药物提供了有希望的途径.

关键词:
模拟MD的模拟方法癌症 癌症 癌症 癌症 癌症激酶激酶的作用是什么谢林阿尔金因蛋白质激酶的作用.气良好的元动力学.

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