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介素-18结合蛋白可以防止代谢性脂肪肝炎的发生
Emmanuel Somm1,2,3, Yunju Jo4,5, Elodie Perroud1,2,3
1Service of Endocrinology, Diabetes and Metabolism, Department of Medicine, Geneva University Hospitals/University of Geneva, Geneva, Switzerland.
Hepatology communications
|November 23, 2025
概括
介素-18结合蛋白 (IL-18BP) 通过减少肝炎和纤维化,限制了与代谢功能障碍相关的脂肪肝炎 (MASH) 的进展. 增加IL-18BP为MASH患者提供了一个新的治疗策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 代谢疾病 代谢疾病
背景情况:
- 代谢功能障碍相关的脂肪肝炎 (MASH) 与西方饮食和肝脏脂肪有关.
- 众所周知,互乐金-18结合蛋白 (IL-18BP) 抑制了互乐金-18 (IL-18) 的活性.
- 对于IL-18BP在MASH病原发生中的特定作用仍然在很大程度上是未知的.
研究的目的:
- 阐明IL-18BP在MASH进展中的作用.
- 研究IL-18BP作为MASH的潜在治疗点.
主要方法:
- 从MASH患者和小鼠模型中分析肝脏转录组.
- 在人类和小鼠肝脏中评估IL-18途径组件的细胞特异表达.
- 对高脂肪/高胆固醇饮食中的Il18bp-/-小鼠进行表型分析.
- 在MASH模型中使用抗IL-18抗体进行治疗干预.
- 对Il18bp-/-Ifng-/-双淘汰赛小鼠的研究.
主要成果:
- 在MASH肝脏中,IL-18BP表达升高,与纤维化严重程度相关.
- 与野生类型对照相比,Il18bp-/-小鼠表现出恶化的肝损伤,炎症和纤维化.
- 反IL-18抗体治疗在Il18bp-/-小鼠中逆转了肝脏病理,在野生型小鼠中改善了MASH.
- 在Il18bp-/-小鼠中的IFN-γ缺乏减少了炎症,但没有纤维化.
结论:
- 通过减轻炎症和纤维化,IL-18BP在MASH中起着保护作用.
- 由IFN-γ介导的IL-18信号驱动着MASH的炎症,但不是纤维化.
- 增加IL-18BP水平为MASH管理提供了一个有希望的治疗途径.
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