阻塞性睡眠呼吸暂停的积极保守干预:一个总体综述和系统综述的元元分析
Cristian Justribó-Manion1, Eleuterio A Sánchez-Romero2, Juan-Nicolás Cuenca-Zaldivar3
1Escuela Internacional de Doctorado (CEINDO), Universitat Abat Oliva CEU, CEU Universities, Bellesguard street 30, Barcelona, 08022, Spain; Faculty of Economics and Social Sciences, University of Applied Sciences Osnabrück, Osnabrück, Germany.
Sleep medicine
|November 23, 2025
概括
同时的运动 (CE) 和口腔肌功能疗法 (OMT) 对阻塞性睡眠呼吸暂停 (OSA) 提供有限的益处. 证据确定性非常低,这表明这些干预措施可能会补充对特定患者的标准护理.
科学领域:
- 睡眠医学 睡眠医学
- 呼吸系统医学 呼吸系统医学
- 基于证据的医学基于证据的医学.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是常见的,并具有严重的健康影响.
- 像CPAP这样的标准治疗方法的坚持率很低.
- 积极的保守干预 (运动,肌功能疗法) 是潜在的替代方案.
研究的目的:
- 进行对元分析的综合审查.
- 评估和比较OSA积极保守干预措施的有效性.
- 评估这些干预措施的证据的确定性.
主要方法:
- 在六个数据库中进行系统搜索.
- 包括对中度有氧运动 (MAE),并发运动 (CE),呼吸肌训练 (RMT) 和口肌功能疗法 (OMT) 的元分析.
- 评估方法质量 (AMSTAR-2),证据确定性 (GRADE) 和研究重叠 (CCA).
主要成果:
- 同时炼 (CE) 和口腔肌功能疗法 (OMT) 显示出最一致的无呼吸-低呼吸指数 (AHI) 减少.
- 来自CE和OMT的改善独立于BMI变化,并且与更好的睡眠质量和减少白天嗜睡有关.
- 对呼吸肌肉训练 (RMT) 的证据有限;中度有氧运动 (MAE) 的结果有变化. 总体而言,证据的确定性非常低.
结论:
- 同时炼 (CE) 和口肌功能疗法 (OMT) 对OSA提供了一致但适度的益处.
- 这些发现基于非常低的确定性证据,表明它们可能是标准护理的附加剂.
- 需要高质量的试验来确认这些干预措施的临床效用.
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