工作记忆能力预测大麻对酒精冲动产生的影响
Rachel L Gunn1, Lindy K Howe2, Holly K Boyle3
1Center for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI 02903, USA; Alpert Medical School of Brown University, Department of Psychiatry and Human Behavior, Providence, RI, USA.
Addictive behaviors
|November 23, 2025
概括
更高的工作记忆能力 (WMC) 与使用较高剂量的大麻后减少酒精冲动有关. 低WMC的个体可能不会体验到这些大麻降低酒精消费的好处.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
背景情况:
- 大麻对酒精冲动的影响有所不同,可能是由于个体差异.
- 工作记忆能力 (WMC) 影响药物暗示反应和酒精使用.
- 以前的研究表明,大麻-酒精冲动关系的结果各不相同.
研究的目的:
- 调查WMC是否能缓解大麻对酒精冲动的急性影响.
- 检查不同WMC措施与大麻使用后的酒精冲动之间的关系.
主要方法:
- 一个随机的,安慰剂控制的交叉试验,涉及125名参与者 (21-44岁) 沉重的酒精和频繁使用大麻.
- 参与者在三个实验室会议中吸食安慰剂,3.1%的THC和7.2%的THC大麻香烟.
- 在大麻管理之前,使用n-back,操作跨度 (OS) 和对称跨度 (SS) 任务来评估工作记忆能力.
主要成果:
- 通过SS测量较高的WMC与与安慰剂相比,在7.2%THC剂量后显著降低酒精冲动相关.
- 对于3.1%的THC剂量或OS任务,没有发现WMC对酒精需求的显著适度.
- 较低的WMC,由n-back分数表明,与更高的整体酒精冲动有关,但没有缓解大麻的影响.
结论:
- 在大麻使用后,具有较高WMC体验的个体急性减少了酒精冲动,特别是在较高THC剂量后.
- 大麻作为酒精替代品的潜在益处可能对WMC较低的人来说是有限的.
- 调查结果强调WMC是理解大麻使用和酒精冲动之间的细微关系的关键因素.
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