免疫检查点的胃肠道并发症 抑制剂治疗 抑制剂治疗
Franck Carbonnel1, Antoine Martin2, Lysiane Marthey2
1Department of Gastroenterology, Kremlin Bicêtre Hospital, Assistance Publique-Hopitaux de Paris, Le Kremlin Bicêtre, France; Paris Saclay University, Le Kremlin Bicêtre, France; Université Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, Villejuif, France.
免疫检查点抑制剂 (ICI) 改善癌症治疗,但可能导致胃肠道免疫相关不良事件 (GI-irAE). 及时诊断和管理,包括皮质类固醇和非响应患者的因弗利克西马布,对于患者护理至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 免疫检查点抑制剂 (ICI) 通过增强抗癌免疫力,显著改善癌症预后.
- 然而,ICI可以诱导与免疫相关的不良反应 (irAE),特别是影响胃肠道 (GI),发生在7-30%的患者中.
- 越来越多的ICI使用需要对GI-irAE有明确的理解,以管理瘤学家,胃肠病学家和初级保健医生.
研究的目的:
- 总结ICI诱导的GI-irAE的发生率,危险因素,临床表现和管理策略.
- 为医疗保健专业人员提供指导,帮助遇到这些不良事件的患者.
主要方法:
- 文献综述和关于GI-irAE的当前数据的综合.
- 对发病率,确定的风险因素和描述的临床表现的分析.
- 评估既定和新兴的管理协议.
主要成果:
- 胃肠道-irAE影响了接受ICI治疗的显著比例的患者.
- 关键的管理步骤包括排除其他诊断,评估严重程度,使用皮质类固醇,并考虑用于耐火病例的infliximab.
结论:
- 为了有效地管理GI-irAE,需要采取系统的方法.
- 早期识别和适当的干预,包括及时使用infliximab,对于优化患者的治疗结果和耐受ICI治疗至关重要.
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